Brain miswiring in tuberous sclerosis and autism

These diffusion tensor images of the brain illustrate the disorganization of nerve fibers in a 17-year-old girl with tuberous sclerosis complex (TSC) and autism (left) as compared with a healthy girl of the same age (right). In the affected girl, the tracts of nerves that carry information from the brain's thalamus to the visual cortex are less organized, with far fewer axons connecting to the cortex. The brighter colors in the healthy brain illustrate greater structural integrity of the tracts. Courtesy Simon Warfield, PhD.


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